1T-LSD (1-(thiophene-2-carbonyl)-lysergic acid diethylamide) is a synthetic lysergamide derivative that is structurally related to LSD. It possesses a thiophene-2-carbonyl group at the N1 position, which distinguishes it from other analogues. 1T-LSD was first identified in 2023 in Japan and Germany and was found in blotting paper products that were mislabeled as other substances.
Pharmacologically, 1T-LSD acts as a prodrug that is converted into LSD in vivo and exhibits LSD-like effects in animal models. Analytical studies have characterized its unique chemical profile and aid in forensic identification.
